孕期空气污染物暴露与巨大儿以及儿童期超重肥胖发生风险的前瞻性队列（英文）

孕期空气污染物暴露与巨大儿以及儿童期超重肥胖发生风险的前瞻性队列（英文）

【摘要】：Background:Decreased semen quality has been associated with ambient fine particulate matter(PM_(2.5)),but its associations with PM_(2.5) constituents are still unknown.Objectives:To quantitatively investigate exposure-response relationships between PM_(2.5) constituents and semen quality.Methods:We studied 1081 men whose partners underwent assisted reproductive technology procedures in a large reproductive medical center in Wuhan,China,and examined their semen quality at least once between 2013 and 2015.Daily PM_(2.5) constituents(metals and water-soluble ions) were continuously determined at two monitoring stations for one week each month.Linear mixed models were used to examine the associations of exposures to PM_(2.5) and its constituents during 90 days before semen examination with semen quality.Results:In consistent with our previous study,PM_(2.5) exposure was significantly associated with decline in sperm concentration(β:-0.12;95%CI:-0.21,-0.03) and sperm count(P:-0.10;95%CI:-0.19,-0.01).We also observed significant associations of PM_(2.5) constituents including Cd,Pb,Mn and Ni with decreased sperm concentration and sperm count(all P for linear trend <0.05).In addition,both Pb and Mn exposures were inversely associated with sperm motility(all P for linear trend <0.05).Sensitivity analyses showed that these associations were relatively robust across different models.Conclusions:Our findings suggest that PM_(2.5) and its constituents(Cd,Pb,Mn and Ni)adversely affect semen quality,especially sperm concentration and count,and add further evidence to reduce ambient PM_(2.5) exposure for men trying to conceive.

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