首页资讯认知功能减退患者的新型[18F]92 β 淀粉样蛋白 PET 成像研究

认知功能减退患者的新型[18F]92 β 淀粉样蛋白 PET 成像研究

来源：泰然健康网时间：2024年12月15日 09:59

Ming Ni, Xingxing Zhu, Kaixuan Wang, Wenliang Guo, Qin Shi, Yuying Li, Mengchao Cui* and Qiang Xie*,

摘要

[18F]-4-((E)-((E)-4-(2-(2-(2-氟乙氧基)乙氧基)乙氧基)亚苄基)-肼基)甲基)-N-甲基苯胺（[18F]92）是一种新型正电子发射断层扫描（PET）示踪剂，以前曾报道过它与聚集的β淀粉样蛋白（Aβ）具有很高的结合亲和力。本研究旨在报告[18F]92的全自动放射合成过程，探索其在健康受试者大脑中的放射性分布，并研究其在阿尔茨海默病（AD）早期诊断中的潜在应用价值。[18F]92的全自动放射合成是在AllinOne模块上完成的。这项研究招募了 31 名参与者。在 0-90 分钟内进行动态[18F]92 PET 成像，以评估认知正常（CN）受试者的时间-活动曲线（TAC）和标准化摄取值比（SUVR）曲线。所有参与者均被目测分为阳性（+）或阴性（-）。通过计算不同相关区域的 SUVR，对[18F]92 进行了半定量分析。此外，研究还分析了全局 SUVR 与血浆 AD 生物标志物（包括 Aβ42、Aβ40、P-tau181 和 T-tau）之间的关系。[18F]92的自动放射合成在50分钟内完成，放射化学纯度超过95%，放射化学产率为36±3%（非衰变校正）。参与者中，15 人估计为 Aβ (-)，16 人估计为 Aβ (+)。TAC显示，[18F]92在10分钟内迅速穿过血脑屏障，随后迅速下降，在最后50-90分钟内下降速度减慢。SUVR曲线显示，SUVR值在注射后60-70分钟左右趋于稳定，在70-90分钟之间达到平衡，主要集中在大脑皮层。在大脑皮层内，Aβ (+) 参与者的 SUVR 明显高于 Aβ (-) 参与者。此外，Aβ42和Aβ42/Aβ40比值与总体SUVR呈负相关，而血浆P-tau181和P-tau181/T-tau比值与总体SUVR呈正相关。[18F]92在人脑中表现出良好的药代动力学特性，并且可以大规模自动合成。[18F]92是一种很有前景且可靠的放射性示踪剂，可用于估计Aβ的病理积累，为AD诊断和治疗药物的临床试验提供有价值的帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

Novel β-amyloid PET Imaging Study of [18F]92 in Patients with Cognitive Decline

[18F]-4-((E)-(((E)-4-(2-(2-(2-Fluoroethoxy)ethoxy)ethoxy)benzylidene)-hydrazono)methyl)-N-methylaniline ([18F]92) is a novel positron emission tomography (PET) tracer previously reported to exhibit high binding affinity to aggregated β-amyloid (Aβ). This study aims to report a fully automated radiosynthesis procedure for [18F]92, explore its radioactive distribution in the brains of healthy subjects, and investigate its potential application value in the early diagnosis of Alzheimer’s disease (AD). The fully automated radiosynthesis of [18F]92 was performed on the AllinOne module. Thirty one participants were recruited for this study. Dynamic [18F]92 PET imaging was conducted over 0–90 min period to assess time–activity curves (TAC) and standardized uptake value ratio (SUVR) curves in cognitively normal (CN) subjects. All participants were visually classified as either positive (+) or negative (−). Semiquantitative analyses of [18F]92 were performed by calculating SUVRs in different regions of interest. Furthermore, the study analyzed the relationships between global SUVR and plasma AD biomarkers, including Aβ42, Aβ40, P-tau181, and T-tau. The automated radiosynthesis of [18F]92 was completed within 50 min, yielding a radiochemical purity of greater than 95% and a radiochemical yield of 36 ± 3% (nondecay-corrected). Among the participants, 15 were estimated as Aβ (−) and 16 as Aβ (+). TACs indicated that [18F]92 rapidly crossed the blood–brain barrier within 10 min, followed by a rapid decrease, which then slowed down in the last 50–90 min. SUVR curves revealed that SUVR values stabilized around 60–70 min after injection and reached an equilibrium between 70 and 90 min, primarily in the cerebral cortex. SUVRs of Aβ (+) participants were significantly higher than those of Aβ (−) individuals within the cerebral cortex. In addition, Aβ42 and the Aβ42/Aβ40 ratio exhibited negative correlations with global SUVR, while plasma P-tau181 and the P-tau181/T-tau ratio displayed positive correlations with global SUVR. [18F]92 exhibits excellent pharmacokinetic properties in the human brain and can be synthesized automatically on a large scale. [18F]92 is a promising and reliable radiotracer for estimating Aβ pathology accumulation, providing valuable assistance in AD diagnosis and guiding clinical trials of therapeutic drugs.

认知功能减退患者的新型[18F]92 β 淀粉样蛋白 PET 成像研究

摘要

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认知功能减退患者的新型[18F]92 β 淀粉样蛋白 PET 成像研究

摘要

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从出汗看健康 出汗透露你的健康信号

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从出汗看健康出汗透露你的健康信号